腎癌骨轉(zhuǎn)移-菲律賓 Kidney cancer with bone metastasis-Philippines
一年前在菲律賓馬尼拉一個(gè)會(huì)議上，突然一個(gè)50多歲女士來(lái)到廣州復(fù)大腫瘤醫(yī)院徐克成院長(zhǎng)面前，徐院長(zhǎng)對(duì)她的面孔很熟，但一下子想不起她是什么病患者。她說(shuō)：“徐教授，你是大恩大德的貴人，你看，我有病嗎？”徐院長(zhǎng)想起來(lái)了，她是一位轉(zhuǎn)移性腎癌患者，叫Rus。5年前做過(guò)手術(shù)切除。3年前，即2008年，來(lái)到廣州復(fù)大腫瘤醫(yī)院，已有骨轉(zhuǎn)移。對(duì)于這種進(jìn)展性腎癌，化療和放療無(wú)效，患者5年生存率從0%到13%。徐院長(zhǎng)對(duì)她實(shí)施了聯(lián)合免疫（CIC）治療?？戳怂罱诜坡少e檢查的CT片，基本上看不到病變了。她送給徐院長(zhǎng)兩個(gè)啤酒瓶，上面是繪制的花朵，說(shuō)這是她親手繪的，按照她家族的風(fēng)俗，這些“瓶上畫”代表了最尊敬人的感激。她怕徐院長(zhǎng)不肯收下，說(shuō)：她是窮人，不能送貴重物件給他，也不敢送值錢東西給他，因?yàn)樗缽?fù)大醫(yī)院拒收禮品的規(guī)矩，但這是不值錢的東西，但代表了她的心。徐院長(zhǎng)接受了，雖然不完全理解這種畫的含義，但他帶回了這兩個(gè)啤酒瓶，把它放在辦公桌后書櫥里，天天能看到。
One year ago， at a seminar in Manila， Philippines， a fifty-year-old lady suddenly came to Prof. Xu Kecheng， her face was familiar， but Prof. Xu could not recall which kind of cancer she had(Figure 9). She said， “Professor Xu， you are my great benefactor， do you think that I am still sick？” I recognized that she was a patient with metastatic renal carcinoma， her name was Rus. Five years ago she had surgery. Three years ago， the patient came to our hospital with bone metastasis. For this kind of progressive renal cancer， chemotherapy and radiotherapy do not work at all. There are ten reports showing that patients with a 5-year survival rate vary from 0-13%. Prof. Xu treated her with Combined Immunotherapy for Cancer (CIC)， which she unexpectedly greatly benefited from. Prof. Xu read her latest CT films done in the Philippines and no lesions could be seen. She gave Prof. Xu two beer bottles with flowers that she herself had painted on as gifts. According to her family's custom， these flowers on beer bottle represent their cordial respects and gratitude. She was afraid Prof. Xu would not accept them， saying that she was too poor to send him valuables， she also did not dare send him valuables as she knew there is a rule in our hospital that all staffs are not allowed to accept gifts from patients. These were not valuables， but a token of her regards， so Prof. Xu accepted. Although Prof. Xu cannot fully understand the true meaning of the painting， he brought back these two beer bottles and put them on the bookcase in his office where he can see them everyday.
2011年11月19日，徐克成院長(zhǎng)在馬尼拉受到菲律賓副總統(tǒng)比奈的約見。Rus聽說(shuō)副總統(tǒng)要見徐院長(zhǎng)，大早就來(lái)到徐院長(zhǎng)住的酒店，跟著進(jìn)了副總統(tǒng)府。比奈副總統(tǒng)聽了徐院長(zhǎng)介紹后，很激動(dòng)，高興地與Rus姐妹照相。
On November 19， 2011， the vice president Mr. Binay made an appointment with Prof. Xu in Manila. Mrs. Rus heard that Mr. Binay wanted to meet Prof. Xu， she came to the hotel that he stayed in early that morning， following Prof. Xu to go to the Vice Presidential Palace. Mr. Binay was very excited after listening to Prof. Xu’s presentation and had his photo taken with Mrs. Rus and her sister.
幾年過(guò)去了，Rus依然健康地生存。徐院長(zhǎng)每次到菲律賓，她總?cè)膛阃野l(fā)表講話，介紹她起死回生的經(jīng)歷。
Several years have passed， Rus is still alive and healthy. Every time Professor Xu goes to the Philippines， she always accompanies him， and shares her anti-cancer experience with those cancer patients who still live in great misery.
Rus 正在癌癥治療講座會(huì)上講述自己的抗癌經(jīng)歷
Rus is sharing her personal anti-cancer experience with others
菲律賓副總統(tǒng)比奈（中）接見Rus女士（左）和她的妹妹
Vice President of the Philippines Binay received Ms. Rus(Left) and her younger sister
Rus 成為復(fù)大志愿者，正在講述癌癥康復(fù)
Rus is sharing her cancer rehabilitation experience as a volunteer of Fuda
Rus
腎癌骨轉(zhuǎn)移 Kidney cancer with bone metastases
女性，58歲。腎癌，腎切除后復(fù)發(fā)骨轉(zhuǎn)移。給予聯(lián)合免疫治療，轉(zhuǎn)移灶消失，無(wú)病生存已6年。
Female， 58 years old， kidney cancer， nephrectomy with recurrent bone metastases. After she received combined immunotherapy， the metastatic lesion disappeared. She has cancer-free survived for 6 years.
Rus治療成功經(jīng)驗(yàn) Treatment Experience
轉(zhuǎn)移性腎癌，尤其已進(jìn)行過(guò)手術(shù)和化放療者，預(yù)后很差，中位生存期不超過(guò)一年。但該患者無(wú)病生存已是第6年。究其原因，與正確施行免疫治療有關(guān)。
Those patients with metastatic kidney cancer who have undergone surgery， chemotherapy and radiotherapy have poor prognosis and their median survival period is less than one year. However， this patient has disease-free survived for 6 years， for which is closely related to immunotherapy.
癌細(xì)胞具有異質(zhì)性，就是說(shuō)癌癥基因表達(dá)多種多樣，在分化過(guò)程中又十分不穩(wěn)定，換句話說(shuō)，今天的癌細(xì)胞不等于明天的癌細(xì)胞。免疫療法抗擊癌細(xì)胞，必須‘千軍萬(wàn)馬’、‘隨機(jī)應(yīng)變’，不能僅用一種免疫方法，要用多種，要隨著癌細(xì)胞的變化采用不同的免疫措施。
Cancer cell is heterogeneous， which means cancer gene expression varies and it is very unstable during the differentiation. In other words， cancer cells change day by day. Immunotherapy shall be powerful and adaptable to fight cancer. The immunological measures used shall vary with cancer cells.
基于上述認(rèn)識(shí)，復(fù)大腫瘤醫(yī)院把各種免疫促進(jìn)的方法組合起來(lái)，形成聯(lián)合免疫療法，還有非特異性免疫刺激療法。這就好比打仗時(shí)，必須有陸軍、海軍、空軍，甚至警察（免疫細(xì)胞和細(xì)胞因子）、情報(bào)人員（DC細(xì)胞），不僅要“擴(kuò)軍”，增加它們的數(shù)目，還要采取措施（非特異性療法），“刺激”它們的積極性，讓他們敢于“沖鋒陷陣”。當(dāng)然，在某個(gè)病人，用哪一種或幾種免疫療法，需要預(yù)先做一些特殊檢查，按照具體病情作出決策，即個(gè)體化。
Based on the above understanding， Fuda Cancer Hospital combine a variety of immunological measures， which is so-called combined immunotherapy (CIC)， including CIK， DC， T cell transfusion therapy， cytokines injection and non-specific immunostimulating therapy. This would be like fighting a battle， the Army， Navy， Air Force， and even the police (immune cells and cytokines)， intelligence agent (DC cells) are indispensable. For immune cells， it shall not only increase their number， but also take measures (non-specific therapy) to stimulate their enthusiasm， so that they dare to make a frontal attack on cancer cells. Of course， in some patients， before they receive one or more immunological measures， some special pre-tests shall be carried out to understand individual differences， on which personalized treatment will be made.
按照Rus的具體情況，復(fù)大專家給她CIC治療，并特別給她長(zhǎng)期的非特異性免疫促進(jìn)治療，重在調(diào)動(dòng)患者天生的抗癌能力，從而使得癌細(xì)胞受到抑制，甚至被消滅（實(shí)際上是凋亡），讓患者長(zhǎng)期生存。這是巨大的成功，可稱為奇跡！
According to Rus’s specific condition， she was recommended to undergo CIC long-term non-specific immune therapy， focusing on mobilizing the initiative of innate anti-cancer ability to inhibit or even eliminate cancer cells (apoptosis)， so she manage to obtain long-term survival. It is a great success， which can be called a miracle！
